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簡(jiǎn)要描述：Pentapharm總部位于瑞士Kaiseraugst 的DSM營(yíng)養(yǎng)品公司，靠近巴塞爾，擁有日本、巴西等
分支機(jī)構(gòu)在內(nèi)的200名員工，

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蛋白酶抑制劑

合成，低分子量絲氨酸蛋白酶抑制劑。范圍包括競(jìng)爭(zhēng)力，以及不可逆抑制劑。應(yīng)用：去除不需要的蛋白水解酶活性，增加色底物檢測(cè)的特異性或保護(hù)特定的蛋白質(zhì)水解降解。

099-11	Pefabloc®FG	H-Gly-Pro-Arg-Pro-OH×AcOH
099-01	Inhibits fibrin polymerisation
126-05	r-Hirudin	C287H440N80O110S6
	Inhibits thrombin
380-03	Pefabloc®PK	C24H26N4O3S×HCl
	For the determination of plasma kallikrein
381-01	Pefabloc® TH	C27H31N5O4S×AcOH
	For the determination of thrombin
381-02	Pefabloc®TH1158	C27H32N6O4S×HCl
	For the determination of thrombin
382-03	Pefabloc®uPA	C32H47N5O5S×HCl
	For the determination of urokinase
383-03	Pefabloc®PL	C31H33N5O4S2×HCl
	For the determination of plasmin
384-01	Pefabloc®Try	C14H12N2O2×HCl×H2O
	For the determination of trypsin-like
384-04	Pefabloc®Try1405	C26H29N5O5S×HCl
	For the determination of trypsin
385-02	H-Glu-Gly-Arg-CMK	C14H25N6O5Cl×2TFA
	For the determination of serine proteases
385-03	Pefabloc®Xa	C20H24N4O5S×HCl
	For the determination of Factor Xa
390-10	Pefabloc®Tryp	C44H44N8O6S2×2HCl
	For the determination of mast cell typtase
391-03	Pefabloc®tPA/Xa	C23H24N4O×2HCl
	For the determination of tPA/Xa
398-01	Pefabloc®SP	C10H10N2O3×HCl
	For the determination of trypsin-like serine proteases
399-01	Pefabloc®SC	C8H10FNO2S×HCl
	For the determination of serine proteases
800277 （1g）	Aprotinin
800348 （100g）	Inhibits serine proteases

Chromogenic Substrates for Thrombin

081-01	Pefachrome® TH 5244	Tos-Gly-Pro-Arg-pNA ·AcOH
081-03	Pefachrome® TH	H-D-CHG-Ala-Arg-pNA · 2AcOH
081-05	Pefachrome® TH 5247	H-D-CHG-But-Arg-pNA · 2AcOH
081-08	Pefachrome® TH 5250	H-D-CHG-Pro-Arg-pNA · 2AcOH
081-09	Pefachrome® TH 5251	H-D-CHA-Ala-Arg-pNA · 2AcOH
081-10	Pefachrome® TH 5252	H-D-CHA-Gly-Arg-pNA · 2AcOH
081-11	Pefachrome® TH 5253	H-D-CHA-Gly-Arg-pNA · 2AcOH
081-15	Pefachrome® TH 5256	CH3OCO-Gly-Pro-Arg-pNA · AcOH
081-17	Pefachrome® TG	H-ß-Ala-Gly-Arg-pNA · 2AcOH
081-66	Pefachrome® TH 8198	H-D-Phe-Pip-Arg-pNA · 2HCl S-2238

Chromogenic Substrates for Factor Xa

085-01	Pefachrome® FXa5277	CH3SO2-D-Leu-Gly-Arg-pNA · AcOH
085-03	Pefachrome® FXa5279	CH3OCO-D-CHG-Gly-Arg-pNA · AcOH
085-05	Pefachrome® FXa5112	C2H5OCO-D-Val-Gly-Arg-pNA · AcOH
085-06	Pefachrome® FXa	CH3OCO-D-CHA-Gly-Arg-pNA · AcOH
085-26	Pefachrome® FXa8592	Cbo-Ile-Glu（γ-OR）-Gly-Arg-pNA · HCl （R=50% ME, 50% H） S-2222
085-27	Pefachrome® FXa8595	Cbo-D-Arg-Gly-Arg-pNA · 2HCl S-2765

Chromogenic Substrates for Factor VII

093-01

Pefachrome® FVIIa

CH₃SO₂·-D-CHA-Abu-Arg-pNA · AcOH

Chromogenic Substrates for Factor IXa

095-01	Pefachrome® FIXa3960	H-D-Leu-PHG-Arg-pNA · 2AcOH
095-02	Pefachrome® FIXa	CH₃SO₂-D-CHG-Gly-Arg-pNA · AcOH

Chromogenic Substrates for Factor XIIa

092-02

Pefachrome® FXIIa

H-D-CHA-Gly-Arg-pNA · 2AcOH

Chromogenic Substrates for Urokinase

082-01	Pefachrome® uPA	Bz-ß-Ala-Gly-Arg-pNA · AcOH
082-02	Pefachrome® uPA5260	Cbo-Glu（OtBu）-Gly-Arg-pNA ·. AcOH
082-33	Pefachrome® uPA8294	pyro-Glu-Gly-Arg-pNA · 2HCl S-2444

Chromogenic Substrates for Tissue Plasminogen Activator

091-01	Pefachrome® tPA	CH₃SO₂-D-CHA-Gly-Arg-pNA · AcOH
091-03	Pefachrome® tPA5312	CH₃SO₂-D-Phe-Gly-Arg-pNA · AcOH
091-05	Pefachrome® tPA5314	CH₃SO₂-D-Abu-Gly-Arg-pNA · AcOH

Chromogenic Substrates for Plasmin

083-01	Pefachrome® PL5261	Tos-Gly-Pro-Lys-pNA · AcOH
083-02	Pefachrome® PL5262	H-D-But-CHA-Lys-pNA · 2AcOH
083-03	Pefachrome® PL5263	H-D-Nva-CHA-Lys-pNA · 2AcOH
083-04	Pefachrome® PL5264	H-D-Nle-CHA-Lys-pNA · 2AcOH
083-09	Pefachrome® PL5268	H-D-Ala-CHA-Lys-pNA · 2AcOH
083-14	Pefachrome® PL5272	H-D-Nle-CHA-Lys-pNA · 2HCl

Chromogenic Substrates for Glandular Kallikrein

088-01

Pefachrome® GK

H-D-Val-CHA-Arg-pNA · 2AcOH

Chromogenic Substrates for Plasma Kallikrein

080-01	Pefachrome® PK 80714	Bz Pro-Phe-Arg-pNA · AcOH
080-03	Pefachrome® PK	H-D-Abu-CHA-Arg-pNA · 2AcOH
080-08	Pefachrome® PK 8092Ca5295	H-D-Pro-Phe-Arg-pNA · 2HCl S-2302

Chromogenic Substrates for Protein Ca

089-02	Pefachrome® PCa	H-D-Lys（Cbo）-Pro-Arg-pNA · 2AcOH
089-03	Pefachrome® PCa5294	H-D-CHA-Pro-Arg-pNA · 2AcOH
089-04	Pefachrome® PCa5295	H-D-CHA-Pro-Arg-pNA · 2AcOH
089-07	Pefachrome® PCa5297	Pad-Pro-Arg-pNA · AcOH
089-08	Pefachrome® PCa3297	Pyr-CHG-Arg-pNA · AcOH

Chromogenic Substrates for the Determination of C1-Esterase

087-01	Pefachrome® C1E5292	C₂H₅CO-Lys（Cbo）-Gly-Arg-pNA · AcOH
087-02	Pefachrome® C1E5293	CH₃OCO-Lys（Cbo）-Gly-Arg-pNA · AcOH
087-03	Pefachrome® C1E 5603	CH₃CO-Lys（Cbo）-Gly-Arg-pNA · AcOH

Chromogenic Substrates for Trypsin

084-01	Pefachrome® TRY5274	Cbo-Val-Gly-Arg-pNA · AcOH
084-03	Pefachrome® TRY5276	Cbo-Gly-D-Ala-Arg-pNA · AcOH
084-04	Pefachrome® TRY	Bz-Val-Gly-Arg-pNA · AcOH

Chromogenic Substrates for the Determination of Bacterial Endotoxins

086-01	Pefachrome® LAL5288	CH₃OCO-D-CHA-Gly-Arg-pNA · AcOH
086-03	Pefachrome® LAL5290	CH₃SO₂·-D-Nle-Gly-Arg-pNA · AcOH
086-06	Pefachrome® LAL	CH₃SO₂-D-CHA-Gly-Arg-pNA · AcOH

Other Chromogenic Substrates

083-05	Pefachrome® PL-Strept	plasminogen-streptokinase complex H-D-Nle-CHA-Arg-pNA · 2AcOH
090-08	Pefachrome® ELA	leucocyte elastase MeOSuc-Ala-Ala-Pro-Val-pNA
090-12	Pefachrome® PAP	papain 3-Phenylpropionyl-Pro-Phe-Arg-pNA · AcOH
090-30	Pefachrome® Col	collagenase （Clostridium histolyticum） Cbo-Gly-Pro-Leu-Gly-Pro-pNA
090-35	Pefachrome® Tryp	Tryptase, Plasmin Tos-Gly-Pro-Lys-pNA · AcOH

Snake Venom Proteins

Activator	Source	Application	Remarks

113-01 / 113-04	Protac®	• Determination of protein C and protein S • Protein C pathway assays	Serine protease Agkistrodon contortrix
116-01	Ecarin	• Prothrombin assay • Determination of hirudin	Metalloprotease, activates specifically prothrombin via meizothrombin, does not need PL and Ca2+ Echis carinatus
119-02	Convulxin	Activation of human plaets via binding and clustering of GPVI-receptors under physiological conditions	Crotalus durissus
121-03	RVV Factor V-Activator	Activation of FV in APC-R assay	Serine protease, not inhibited by AT
121-06	RVV-X	• Determination of FX • Screening assay for lupus anti-coagulants （diluted Russel viper venom test, dRVVT）	Metalloprotease, does also （weakly） activate protein C and factor IX Daboia （Vipera） russelli
800191	Pefakit® Reptilase® Time	Ready-to-use diagnostic reagent for measurement of • functionality of fibrin poly-merisation • afibrinogenemia or hypofibrinogen-emia • hyperfibrinolysis • thrombolytic therapy	CE-marked IVD Bothrops atrox

069-03	Prionex® （sterile hydrolyzed gelatine）	Protein stabilization
116-10	HEPES-buffer	Ecarin
148-03	Gelatine 10% （solution）	Protein stabilization
801682	Rabbit Brain Cephalin	Phospholipid source

Pefakit® APC-R Factor V

Pefakit® APC-R Factor V Leiden
Pefakit® APC-R Factor V Leiden is a plasma based functional assay for the determination of resistance of Factor Va to inactivation by activated protein C （APC） caused by the factor V Leiden mutation （FV:Q506）

Pack:	3 x 2 ml	APC /RVV-V （+APC） Reagent

	3 x 2 ml	RVV-V （-APC） Reagent

	3 x 4 ml	PTA Reagent

	3 x 2 ml	Dilution Plasma

REF:	502-01

Pefakit® APC-R Factor V Leiden Controls
Control plasmas for confirmation of factor V Leiden mutation （FV:Q） in assays for determination of the functional phenotype for activated protein C resistance caused by the factor V Leiden mutation.

Pack:	3 x 1 ml	FV-L Negative Control

	3 x 1 ml	FV-L Heterozygous Control

REF:	502-21

Pefakit® APC-R Factor V Leiden Homozygous Control
Control plasma for confirmation of factor V Leiden mutation （FV:Q） in assays for determination of the functional phenotype for activated protein C resistance caused by the factor V Leiden mutation.

Pack:	3 x 0.5 ml	FV-L Homozygous Control

REF:	502-23

Pefakit® Reptilase®Time

Pefakit® Reptilase®Time
For the investigation of the last phase of blood coagulation. Due to its heparin insensitivity the Reptilase®Time can detect fibrinogen polymerization disorders even in the presence of heparin.

Pack:	3 x 1 ml	Reptilase®Time Reagent

REF:	800191

Pefakit® in-TDT

Pefakit® in-TDT

Determination of initial thrombin formation by intrinsic activation.

Pack: 2 x 2 ml Reagent

2 x 2 ml Activator

2 x 2,5 ml Diluent

1 x 1 ml Calibrator

1 x 1 ml Control N

1 x 1 ml Control P

REF: 800236

You can order your free manual and adaption protocol by clicking on the contact option on top of the screen.

- Manual for the Analysis Software Tool BCS®
- BCS Adaption protocol for Pefakit® in-TDT® Art. 800236

- Manual for the Analysis Software Tool ACL 9000
- ACL-9000 Adaption protocol for Pefakit® in-TDT® Art. 800236

Pefakit® PiCT®

Pefakit® PiCT® - Prothrombinase induced Clotting Time
Pefakit® PiCT® is a plasma based functional assay for the determination of factor Xa and factor IIa inhibitors.

Pack:	3 x 2 ml	PiCT® Activator

	3 x 2 ml	PiCT® Start Reagent


REF:	505-01

Applications for various haemostasis systems on request Applications for direct factor Xa inhibitors on request

Pefakit® PiCT® Calibrators UFH

Pack:	3 x 1 ml	UFH Calibrator 1

	3 x 1 ml	UFH Calibrator 2


REF:	505-121

Pefakit® PiCT® Controls UFH

Pack:	3 x 1 ml	UFH Control 1

	3 x 1 ml	UFH Control 2

REF:	505-22

Pefakit® PiCT® Calibrators LMWH

Pack:	3 x 1 ml	LMWH Calibrator 1

	3 x 1 ml	LMWH Calibrator 2

REF:	505-11

Pefakit® PiCT® Controls LMWH


Pack:	3 x 1 ml	LMWH Control 1

	3 x 1 ml	LMWH Control 2


REF:	505-21

Pefakit® PiCT® Calibrators Hirudin


Pack:	3 x 1 ml	Hirudin Calibrator 1

	3 x 1 ml	Hirudin Calibrator 2

REF:	505-13

Pefakit® PiCT® Controls Hirudin

Pack:	3 x 1 ml	Hirudin Controls 1

	3 x 1 ml	Hirudin Controls 2


REF:	505-23

Pefakit® TAFI

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pentapharm公司產(chǎn)品

Other Chromogenic Substrates

Snake Venom Proteins

Pefakit® APC-R Factor V

Pefakit® Reptilase®Time

Pefakit® in-TDT

Pefakit® PiCT®

Pefakit® TAFI

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