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簡(jiǎn)要描述：美國(guó)Stemgent公司干細(xì)胞專家。它的宗旨是為生物科研工作者提供干細(xì)胞研究的試劑與試劑盒。 背景知識(shí)：干細(xì)胞是在動(dòng)物體內(nèi)存在的一種極特殊的細(xì)胞。這種細(xì)胞可以無窮盡的分裂，也可以變成或分化成體內(nèi)各種組織器官的細(xì)胞。胚胎干細(xì)胞可以形成完整的胚胎或個(gè)體
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美國(guó)Stemgent公司干細(xì)胞專家。它的宗旨是為生物科研工作者提供干細(xì)胞研究的試劑與試劑盒。 背景知識(shí)：干細(xì)胞是在動(dòng)物體內(nèi)存在的一種極特殊的細(xì)胞。這種細(xì)胞可以無窮盡的分裂，也可以變成或分化成體內(nèi)各種組織器官的細(xì)胞。胚胎干細(xì)胞可以形成完整的胚胎或個(gè)體。這就是個(gè)體克隆。Stemgent的宗旨是提供各種試劑與試劑盒，配備生物科研人員新的研究工具與手段。
相關(guān)產(chǎn)品：
Viruses 病毒
Small Molecules 小分子
Matrices 基質(zhì)膠
Cell Lines 細(xì)胞
Antibodies / Biomarkers 抗體和標(biāo)記物
Cytokines 細(xì)胞因子
Transfection 轉(zhuǎn)染試劑
Primary Cells 原代細(xì)胞
Media 培養(yǎng)基
公司:https://www.stemgent.com
| Small Molecules |
| Stemolecule™ Thiazovivin , Cat. No. 04-0017 Stemolecule™ Thiazovivin dramatically improves the survival of hESCs upon trypsinization1. Thiazovivin in combination with inhibitors of the TGFβ receptor and the MEK pathway improve reprogramming efficiency more than 200-fold1. |
| Stemolecule™ Rock II Inhibitor , Cat. No. 04-0030 StemoleculeTM Rock II Inhibitor is a specific inhibitor for type 2 Rho-associated, coiled-coil containing protein kinase （Rock）. Rock inhibitors have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem （ES） cells without affecting their self-renewal properties or pluripotency. |
| Stemolecule™ Rock I Inhibitor , Cat. No. 04-0029 Rock inhibitors, including Stemolecule™ Rock I Inhibitor, have been found to prevent apoptosis, as well as enhance the survival and cloning efficiency of dissociated human embryonic stem （ES） cells without affecting their self-renewal properties or pluripotency. |
| Stemolecule™ Cyclic Pifithrin-α , Cat. No. 04-0040 Stemolecule™ Cyclic Pifithrin-α （Cyclic PFT-α） is a transcriptional inhibitor of p53. The reduction of p53 activity has been shown to enhance reprogramming efficiency of human and mouse somatic cells. Cyclic PFT-α sensitizes tumor cells to antimicrotubule agent induced apoptosis. |
| Stemolecule™ Pifithrin-α , Cat. No. 04-0038 Stemolecule™ Pifithrin-α （PFT-α） is a small molecule inhibitor of p53 dependent apoptosis and transcriptional activation for cyclin G, p21/waf1, and mdm2 expression. The reduction of p53 activity has been shown to enhance reprogramming efficiency of human and mouse somatic cells. |
| Stemolecule™ BMP Inhibitor LDN-193189 , Cat. No. 04-0019 StemoleculeTM BMP Inhibitor LDN-193189 functions primarily through inhibition of BMP type I receptors ALK2 and ALK3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK7. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. |
| Stemolecule™ （-）-Indolactam V , Cat. No. 04-0020 StemoleculeTM （-）-Indolactam V is a PKC isozyme inhibitor identified in a high-content chemical screen as a small molecule inducer of human embryonic stem cell differentiation to functional insulin-secreting beta cells at the definitive endoderm cell stage. |
| Stemolecule™ SHH Antagonist , Cat. No. 04-0032 StemoleculeTM SHH Antagonist is an inhibitor of Sonic hedgehog signaling （SHH）. Hedgehog signaling is involved in embryogenesis as well as cancer progression. The mechanism for this antagonist is unknown. |
| Stemolecule™ SMO Antagonist , Cat. No. 04-0031 Stemolecule™ SMO Antagonist is an analog of SANT-2, an inhibitor of Sonic hedgehog signaling. Hedgehog signaling is involved in embryogenesis as well as cancer progression. The mechanism of action of SMO Antagonist is allosteric inhibition of Smoothened （SMO）, an integral membrane protein mediator of Hedgehog signaling. |
| Stemolecule™ Wnt Inhibitor IWP-4 , Cat. No. 04-0036 Stemolecule™ Wnt Inhibitor IWP-4 is an antagonist of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-4 prevents palmitylation of Wnt proteins by Porcupine （Porcn）, a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It blocks phosporylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. |
| Stemolecule™ Wnt Inhibitor IWP-3 , Cat. No. 04-0035 Stemolecule™ Wnt Inhibitor IWP-3 is an antagonist of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-3 prevents palmitylation of Wnt proteins by Porcupine （Porcn）, a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. |
| Stemolecule™ Wnt Inhibitor IWP-2 , Cat. No. 04-0034 Stemolecule™ Wnt Inhibitor IWP-2 is an antagonist of the Wnt/β-catenin pathway1. Wnt Inhibitor IWP-2 prevents palmitylation of Wnt proteins by Porcupine （Porcn）, a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. It blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin1. |
| Stemolecule™ IDE-2 , Cat. No. 04-0027 Stemolecule™ IDE-2 is an inducer of definitive endoderm （IDE） from embryonic stem （ES） cells in mouse and human ES cell cultures1. IDE-2 chemically induced endoderm can continue to differentiate into pancreatic progenitors in vitro and contribute to gut tube formation in vivo when injected into the developing gut tube of mouse embryos. |
| Stemolecule™ IDE-1 , Cat. No. 04-0026 Stemolecule™ IDE-1 is an inducer of definitive endoderm （IDE） from embryonic stem （ES） cells in mouse and human ES cell cultures. Endoderm chemically induced by IDE-1 can continue to differentiate into pancreatic progenitors in vitro and contribute to gut tube formation in vivo when injected into the developing gut tube of mouse embryos. |
| Stemolecule™ Doxycycline hyclate , Cat. No. 04-0016 Stemolecule™ Doxycycline hyclate （Dox）, a derivative of tetracycline, is used to induce expression of the Stemgent® iPSC Generation Dox Inducible products. In the iPSC Generation Dox Inducible protocol, addition of Dox to the culture medium of transduced cells induces the reverse tetracycline transactivator （rtTA） to bind to the Tet response element and results in the transcriptional activation for each of the factors implicated in the reprogramming process. Conversely, Dox can be removed from the medium to suppress transcriptional activation of the reprogramming factors. |
| Stemolecule™ Forskolin , Cat. No. 04-0025 Stemolecule™ Forskolin can potentiate neuron differentiation and can also stimulate adenylate cyclase activity and increase cyclic AMP. Protein kinase A （PKA） activity is dependent upon binding to cAMP and has been implicated in sonic hedgehog signaling. |
| Stemolecule™ Dorsomorphin , Cat. No. 04-0024 Dorsomorphin-2HCl is a potent inhibitor of AMP-activated protein kinase （AMPK） and bone morphogenic protein （BMP） signaling, functioning through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation. |
| Stemolecule™ Dexamethasone , Cat. No. 04-0023 Stemolecule™ Dexamethasone is a glucocorticoid receptor agonist known to affect inflammatory responses, cellular proliferation, and differentiation in target tissues. |
| Stemolecule™ Cyclopamine , Cat. No. 04-0022 Stemolecule™ Cyclopamine has been identified as a specific inhibitor of hedgehog singaling by direct binding to the heptahelical bundle of Smoothened. Hedgehog signaling is involved in embryogenesis as well as cancer progression. Cyclopamine has been utilized as a small molecule inducer of stem cell differentiation towards definitive endoderm pancreatic islet cells, as a modulator of cell proliferation, and as an anticancer drug. |
| Stemolecule™ All-Trans Retinoic Acid , Cat. No. 04-0021 Stemolecule™ All-Trans Retinoic Acid functions as a signaling molecule for various developmental pathways that control differentiation and proliferation. It has been used in various differentiation protocols, including B-cells, T cells and neurons, and implicated in specification of the embryonic anterior/posterior axis through Hox gene regulation. |
| Stemolecule™ KAAD-Cyclopamine , Cat. No. 04-0028 Stemolecule™ KAAD-Cyclopamine is a sonic hedgehog antagonist known to target Smoothened. Hedgehog signaling is involved in embryogenesis as well as cancer progression. KAAD-Cyclopamine has been utilized to halt the migration or proliferation of a variety of cancer cells. |
| iPSC Generation |
| Stemolecule™ Tranylcypromine hydrochloride , Cat. No. 04-0033 Stemolecule™ Tranylcypromine inhibits BHC110/LSD1, a histone H3 lysine 4 demethylation enzyme with close homology to monoamine oxidases. Treatment of P19 embryonal carcinoma cells with tranylcypromine resulted in global increase in H3K4 methylation as well as transcriptional derepression of the pluripotent stem cell marker Oct4. |
| Kits / Sets |
| Stemolecule™ MAPK Signaling Pathway Modulator Set , Cat. No. 00-0041 The Stemolecule™ MAPK Signaling Pathway Modulator Set consists of three cell-permeable small molecules: PD0325901, PD173074, and SC1 （Pluripotin）, which can modulate the MAPK signaling cascade. PD0325901 is a MEK inhibitor; PD173074 is an ATP-competitive inhibitor of the FGF receptor, known to activate the MAPK/ERK cascade; and SC1 （Pluripotin） acts through dual inhibition of ERK 1 and Ras-GAP. Each small molecule is tested for purity, accurate mass and structure, and toxicity in mouse embryonic stem cells. |
| Stemolecule™ iPS Cell Enhancer Set , Cat. No. 00-0040 The Stemolecule™ iPS Cell Generation Enhancer Set is a proven set of small molecules designed to improve iPS cell generation efficiency. The set consists of four cell-permeable small molecules: RG108, BIX1294, Valproic Acid （VPA）, and R（+）Bay K 8644. |
| Stemolecule™ Epigenetic Modifier Set , Cat. No. 00-0039 The Stemolecule™ Epigenetic Modifier Set is a complete set of small molecules for modulating epigenetic effects of DNA and histones. The set consists of four cell-permeable small molecules: BIX01294, Sodium Butryate, RG108, and Valproic Acid （VPA）. BIX01294 is a selective inhibitor of G9a HMTase, Sodium Butryate is an inhibitor of histone deacetylases, RG108 is a DNA methyltransferase inhibitor, and VPA is an inhibitor of histone deacetylases. Each small molecule is tested for purity, accurate mass and structure, and toxicity in mouse embryonic stem cells. |
| Stemolecule™ TGF-beta Signaling Pathway Modulator Set , Cat. No. 00-0038 The Stemolecule™ TGF-β Small Molecule Set is an inclusive set of small molecules for regulating the transforming growth factor beta （TGF -β） signaling pathway. The set consists of three Stemolecules™, SB431542, A83-01, and ALK5 Inhibitor: activin receptor-like kinase （ALK） receptors that work as TGF-β. Each small molecule is tested for purity, accurate mass and structure, and toxicity in mouse embryonic stem cells. |
| Components |
| Stemolecule™ ALK5 Inhibitor , Cat. No. 04-0015 ALK5 Inhibitor is a potent small molecule that selectively inhibits the TGF-β signaling pathway. |
| Stemolecule™ A83-01 , Cat. No. 04-0014 A83-01 is a potent small molecule that selectively inhibits ALK4, ALK5, and ALK7 receptors. This small molecule has been used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state. |
| Stemolecule™ BIO , Cat. No. 04-0003 BIO is the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.1 |
| Stemolecule™ CHIR99021 , Cat. No. 04-0004 CHIR99021 is the most selective inhibitor of GSK3β. |
| Stemolecule™ Sodium Butyrate , Cat. No. 04-0005 In cultured mouse and human cells, sodium butyrate has been shown to inhibit both the mRNA and protein content of cyclin D1.1 Sodium butyrate is a known inhibitor of histone deacetylases.2 |
| Stemolecule™ Purmorphamine , Cat. No. 04-0009 Stemolecule™ Purmorphamine promotes the differentiation of human and murine mesenchymal progenitor cells into osteoblasts.1,2 It is ideal for stem cell and cell signaling researchers using human embryonic stem cells to investigate differentiation with small molecules. |
| Stemolecule™ SB431542 , Cat. No. 04-0010 SB431542 has been shown to stimulate proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells via ALK receptor inhibition.1,2 |
| iPSC Generation Components |
| Stemolecule™ PD173074 , Cat. No. 04-0008 PD173074 inhibits the FGF signaling pathway. |
| Stemolecule™ Valproic Acid , Cat. No. 04-0007 VPA has been shown to enhance iPS generation in a three-factor transduction （Oct4, Klf4 and Sox2） without introduction of the c-Myc oncogene.1 |
| Stemolecule™ PD0325901 , Cat. No. 04-0006 PD0325901 selectively binds and inhibits MEK, which may result in the inhibition of the phosphorelation and activation of MAPK/ERK.1,2 |
| Stemolecule™ SC1 （Pluripotin） , Cat. No. 04-0011 SC1 （Pluripotin） is a high-quality, affordable small molecule LIF replacement for mouse embryonic （mES） cell self-renewal. SC1 maintains mES cells in an undifferentiated self-renewal state in the absence of LIF, feeder cells, or serum. |
| Stemolecule™ Y27632 , Cat. No. 04-0012 Y27632 is a Rho-associated kinase ROCK inhibitor that enhances survival and cloning efficiency of human embryonic stem cells. |
| Stemolecule™ R（+）Bay K 8644 , Cat. No. 04-0013 R（+）Bay K 8644 is a small molecule that enhances reprogramming efficiency when used with BIX01294. |
| Stemolecule™ BIX01294 , Cat. No. 04-0002 BIX01294 enhances reprogramming efficiency of neural progenitor cells to the same levels as when four transcription factors （Oct4, Klf4, Sox2 and c-Myc） were introduced to somatic cells.1,2 |
| Stemolecule™ RG108 , Cat. No. 04-0001 Stemolecule™ RG108 is the highest purity preparation available, only from Stemgent. RG108 is a cell-permeable, specific DNA methyltransferase inhibitor that displays anti-proliferative properties with no detectable cytotoxic effects.1 |
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