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            當前位置:首頁 > 新聞中心 > Imgenex公司表觀遺傳學研究工具:Dnmt與HDAC抗體

            Imgenex公司表觀遺傳學研究工具:Dnmt與HDAC抗體

            更新時間:2011-10-05      點擊次數:5220

            Imgenex公司表觀遺傳學研究工具:Dnmt與HDAC抗體
             
            Dnmt and HDAC Antibodies for Epigenetics
            Cell Regulation & DNA Repair
             
            Histonedeacetylases exert transciptional control through deacetylation of core histone proteins. DNA methyltransferases regulate gene expression through cytosine methylation –changes in methylation patterns have been linked with neoplasia development. As a recognized leader and tool provider for cell regulatory pathway analysis, IMGENEX provides a comprehensive choice of highly referenced, validated antibodies specific for HDACs and Dnmts. We are continuing to build upon our leading portfolio for studying cell regulation by introduction of new products including transcription factors, ChIP Kits, signaling molecules and other key biomarkers. Utilization of our Pathway Profiling expertise and products continues to enable advanced research in Cancer, Apoptosis, Stem Cell/Developmental Biology and Immune/Inflammation Signaling Pathways.
             
            Applications:
            •  Western Blot
            •  IHC
            •  ChIP
            •  Flow Cytometry
             
             
            HDAC Antibodies
            HDAC-1 HDAC-6
            HDAC-2 (Ab-394) HDAC-7
            HDAC-3 HDAC-7 (Ser155)
            HDAC-4 HDAC-7 (Ser318)
            HDAC-4 (Ab-632) HDAC-7 (Ser448)
            HDAC-4 (Ser632) HDAC-8 (Ab-39)
            HDAC-5 HDAC-8 (Ser39)
            HDAC-5 (Ab-498) HDAC-9
            HDAC-5 (Ser498)  
             
            Dnmt Antibodies
            Dnmt1 Dnmt3a
            Dnmt2 Dnmt3b
             
            Related Pathways
            Transcription Factors
            Apoptosis Detection Kits/pSIVA
            NF-kB Pathway
             
            Dnmt3a, IMG-268A
            Expression of Dnmt3a in the nuclei of post-mitotic neurons in the olfactory epithelium (OE). DNMT3a (red) is co-expressed with neuron-specific tubulin (green) throughout the development of the olfactory epithelium, using IMG-268A. (Data courtesy of A. Jane Roskams, University of British Columbia).
             
            HDAC-7 (Ser155), IMG-612
            Western blot analysis of phosphorylated HDAC-7 in (A) recombinant fusion protein containin a phosphorylated serine at position 155 and (B) fusion protein containing an unphosphorylated serine at position 155, using IMG-612 at 0.1 ug/ml.

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