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世界*實驗材料供應商 Schircks正式授權上海起發為其中國代理， Schircks在一直是行業的*,一直為廣大科研客戶提供zui為的產品和服務,上海起發一直秉承為中國科研客戶帶來的產品，的服務，簽約 Schircks就是為了給廣大科研客戶帶來更加完善的產品和服務,您的滿意將是我們zui大的收獲
Schircks中國代理, Schircks上海代理， Schircks北京代理，Schircks廣東代理， Schircks江蘇代理Schircks湖北代理,Schircks天津,Schircks黑龍江代理,Schircks內蒙古代理,Schircks吉林代理,Schircks福建代理, Schircks江蘇代理, Schircks浙江代理, Schircks四川代理,
Schircks Laboratories由B. Schircks博士在瑞士成立，1980合成蝶啶。該公司是獨立經營的。schircks實驗室已經停止生產四氫生物蝶呤。BIOMARIN已經接管了美國市場，默克雪蘭諾公司歐洲市場。他們將繼續擴大。他們是負責供應（鹽酸沙丙蝶呤呤）片劑（含量）。
超過100的schircks實驗室其他蝶啶類化合物主要用于科學和臨床診斷應用的合成。我們不斷開發和改進合成，并開始新的合成，以滿足世界各地的研究和開發小組的需求。
Methotrexate
Product No. 16.411
Synonym: Amethopterin, N-methylamino}benzoyl}-L-glutamic acid
Abbreviation used: MTX
Description | Yellow to orange brown crystalline powder |
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Biochemistry | Methotrexate is an antimetabolite. It is an inhibitor of dihydrofolate reductase. MTX acts by | |||||
| altering the body's use of folic acid (a vitamin), which is needed for cell growth. It is | |||||
| suspected that this interference with folic acid is an important reason for methotrexate's | |||||
| benefit in rheumatoid arthritis. |
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Solubility | MTX is practically insoluble in water. It is sparingly soluble in 0.01 M NaOH pH 10.0, | |||||
| (0.25 g/100 g 0.01 M NaOH (22°C)). Ultrasonication may be used to improve dissolution. | |||||
HPLC Conditions | column |
| Waters Spherisorb S5-ODS1 |
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| eluant |
| 10 mM Na2HPO4 pH 6.0 / Methanol (19:1) | |||
| flow rate |
| 1 ml/min |
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| wavelength |
| 254 nm |
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| solution |
| 1 mg/ml 0.01 M NaOH |
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Purity: HPLC | >98.5%. Related substances are N-methylfolic acid, 4-aminofolic acid, 2,4-diami0- | |||||
| methylpteroic acid and 10-methylpteroic acid. |
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Stability | Methotrexate powder is stable at room temperature for at least 3 months. It is hygroscopic. | |||||
| A 1 mM solution of MTX in 0.01 M NaOH is very stable. HPLC analysis of the 1 mM solution | |||||
| after 7 days at room temperature showed no degradation. | |||||
Storage | Keep the powder dry in amber vials at –20°C or colder. Methotrexate can be transported | |||||
| without the use of dry ice. |
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Uses | MTX was first developed to treat certain types of cancer. It is routinely used at high doses | |||||
| as a cancer therapy and is also used at much lower doses to treat neoplastic diseases, | |||||
| severe psoriasis, Crohn's disease and adult rheumatoid arthritis. Our product is sold for | |||||
| laboratory use only. |
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Precautions | Highly Toxic. Use Special Handling precautions. Avoid inhalation and skin contact. | |||||
| Side effects to the use of this drug may include suppression of bone marrow production of | |||||
| blood cells, hepatitis, and others. |
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References | "Taber's Cyclopedic Medical Dictionary", Copyright © 2001 by F. A. Davis Co., Phil., PA. | |||||
我們公司zui大優勢是強大的采購，
1：基本什么都能進口，血清，抗體，耗材，還有部分限制進口的，
2：貨品全，現經營過700多個品牌，基本所有生物試劑耗材都可以進口，特別是冷偏的產品那就更有優勢，
3：提供加急服務，一般1-2周到貨，超過時限加急費全免
4：價格公道，絕大部分價格有優勢，當然不能保證100%產品都是,因為意味著沒有服務.
5：良好的信譽，大部分客戶我們提供貨到付款服務，客戶包括清華，北大 交大 復旦，中山等100多所大學，ROCHE，阿斯利康，國藥 ，fisher等500多家公司
6：我們*代理的品牌有：Antibody Research Corporation，arcticzymes，Biorelevant，AmberGen, Inc. ，clemente-associates，clodronaiposomes，Columbia Biosciences，enzyme research，Gene Bridges GmbH，Genovis，AmberGen, Inc. Biotechnology GmbH，Haematologic Technologies HTI Haemtech，hookelabs，Immudex，Innovative Research of America，inspiralis ，List Biological Laboratories, Inc.，lumafluor，Microsurfaces，multiplicom，nanotools，Pel-Freez Biologicals，pentapharm，progen，Protein Ark，QA-Bio,Inc，QA-Bio,IncQuickZyme Biosciences，Teknova，TriLink BioTechnologies, Inc.，Zyagen Laboratories 等
7：我們還是invitrogen,qiagen,Midland BioProducts Corporationam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知名*批發，歡迎合作。
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