emfret公司血小板消除抗體r300說明書

本產品只用于科研，不用于診斷，也不屬于醫療用品

特異性: This antibody preparation contains a mixture of purified rat monoclonal antibodies  directed against mouse GPIba (CD42b). Targeting of this receptor with divalent IgGs results in profound and irreversible Fc-independent plaet depletion in mice^1,2. Plaet depletion is frequently used to study the general role of plaets in (patho-) physiology³.

制備 :  抗體是雜交瘤細胞上清通過G-Sepharose純化所得，內毒素含量小于 0.0025 EU/µg

保存和運輸：4度保存和運輸，保質期為6個月 ，無菌保存不含防腐劑，分裝保存-20度zui少可以保存一年以上，但請避免反復凍融

使用方法: 按動物體重注射抗體  量為2 µg抗體/g動物體重60分鐘內可以去除血小板95%以上，建議每次注射100-200µL抗體（用無菌PBS稀釋）。

引用文獻: 1. Bergmeier W, Rackebrandt K, Schroder W, Zirngibl H, Nieswandt B. (2000) Structural and functional characterization of the mouse von Willebrand factor receptor GPIb-IX with novel monoclonal antibodies. Blood. 95:886-93.

2. Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, and Zirngibl H. (2000) Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Blood. 96:2520-27.

3. Elzey BD, Tian J, Jensen RJ et al. (2003) Plaet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity.19:9-19.

：    :fige007